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Augment the Human T Cell Activation in Standard 96-well Plates Using the C.BIRD Microbioreactor

T cell-based immunotherapies are popular cancer treatments, and require procuring a large number of T cells. T cells that are isolated from the patient need to be optimally activated and expanded in vitro, then re-infused back to the patient for fighting cancer cells. This study sought to improve the activation level of human T cells in 96-well plates by introducing a novel C.BIRD™ cell culture method.

Study results showed that the C.BIRD cell culture method enhanced the activation level of human T cells, but did not cause unwanted activation. This study demonstrates a great potential to improve T cell-based immunotherapies studies by accelerating the process development workflow.