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S.NEST | An intelligent tool with real-time dissolved oxygen and pH monitoring on batch cultures

Cell growth measurement and metabolism analysis in high-throughput cell culture is a labor-intensive and time-consuming process. Here, we introduced CYTENA BPS’s high-throughput microbioreactor, the S.NEST, and demonstrated the reliability of real-time monitoring functions of dissolved oxygen (DO) and pH.

The DO value was correlated with doubling time and cell viability while the pH value was related to cell metabolism and carbon resource utilization. By using the S.NEST to assess DO and pH, the cell growth and metabolic profile could be predicted without any disturbance. The device could increase the efficiency for cell culture and provide a great platform for process development.

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